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The molecule, BRP, has none of the side effects associated with Ozempic

By James R. Hood of ConsumerAffairs
March 5, 2025

Researchers at Stanford Medicine have discovered a naturally occurring molecule that mimics the effects of semaglutide (Ozempic) in reducing appetite and promoting weight loss, but without some of the drugs common side effects.

The molecule, named BRP, was found to act through a different metabolic pathway than semaglutide, potentially offering a more targeted and effective approach to weight loss. Early animal testing showed that BRP led to significant fat loss while avoiding issues such as nausea, constipation, and muscle losscommon side effects of semaglutide.

How BRP works

The research, published in Nature, highlights that BRP works differently from GLP-1 receptor agonists like Ozempic. While semaglutide activates receptors in the brain, gut, pancreas, and other tissues, BRP appears to act only in the hypothalamus, the brain region that controls appetite and metabolism.

This targeted effect could mean fewer unwanted digestive side effects while still reducing food intake and improving metabolic health.

AI aids discovery

The discovery of BRP was made possible by artificial intelligence (AI). The Stanford team developed an algorithm called Peptide Predictor, which analyzed thousands of proteins to identify potential hormones involved in energy metabolism.

This algorithm was absolutely key to our findings, said Katrin Svensson, PhD, the senior author of the study and an assistant professor of pathology at Stanford.

The AI helped narrow the search to a small peptide made of 12 amino acids, now called BRP, which was found to have a powerful impact on appetite regulation.

Promising results in animals

When tested on lean mice and minipigs, an injection of BRP reduced food intake by up to 50% within an hour. In obese mice, daily injections for 14 days resulted in an average weight loss of 3 grams, mainly from fat loss, while control mice gained weight.

Unlike Ozempic, the treated animals showed no changes in movement, anxiety, or digestive function, suggesting fewer side effects.

Next: Human trials

Svensson has co-founded a company to begin clinical trials on humans. Researchers are also working to identify BRPs specific receptors and optimize its effects for longer-lasting results.

The lack of effective obesity treatments has been a problem for decades, Svensson said. We are eager to see if BRP is safe and effective in humans.

If successful, BRP could become a new alternative to semaglutide-based drugs, offering a powerful weight-loss solution with fewer drawbacks.

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Posted: 2025-03-05 22:57:48

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Consumer News: Amazon rolls out wider same-day pharmacy delivery expansion
Wed, 11 Feb 2026 20:07:07 +0000

The service is set to reach thousands more Americans by 2026

By Kristen Dalli of ConsumerAffairs
February 11, 2026
  • Amazon Pharmacy is rolling out same-day prescription delivery to nearly 4,500 U.S. cities and towns by the end of 2026.

  • The expansion aims to tackle pharmacy closures, staffing shortages, and transportation barriers that make accessing medications hard in many areas.

  • Customers can still use other fast delivery options, savings programs like RxPass, and even in-clinic kiosks in select locations.


If youve ever finished a doctors appointment and wished your medication could be in your hands by dinner, Amazon is working on just that. The company just announced a major expansion of its Amazon Pharmacy same-day prescription delivery service and for a lot more people than ever before.

Previously available in select major cities, same-day delivery is now set to roll out nationwide to almost 4,500 cities and towns across the United States by the end of 2026, adding roughly 2,000 new communities that havent had quick delivery access before.

That means whether you live in a big metro area or a smaller town that lost its local pharmacy, you might soon be able to order your prescription and have it arrive within hours rather than days.

"Patients shouldn't have to choose between speed, cost, and convenience when it comes to their medication, regardless of where they live," John Love, vice president of Amazon Pharmacy, said in a news release.

"By combining our pharmacy expertise with our logistics network, we're removing critical barriers and helping patients start treatment faster setting a new standard for accessible, digital-forward pharmacy care."

Why this matters

Americans are dealing with pharmacy closures, shortages of staff, and long drives to pick up routine meds in many parts of the country especially rural and underserved areas. Amazon says its vast logistics network can fill that gap by bringing medications directly to your door fast, which could be a game changer for people managing chronic conditions or acute illnesses.

To make this work, Amazon uses a mix of delivery methods tailored to the community from e-bikes in dense cities to electric vehicles and even some creative local solutions in remote spots.

Plus, this isnt the only way to get meds: services like two- or three-day shipping still exist for customers everywhere, and Amazon is also growing its in-clinic Pharmacy Kiosks at some One Medical locations so people can pick up meds immediately after a doctor visit.

On the cost side, Amazon Pharmacy offers programs aimed at savings: Prime members can access discounts on generics and brand drugs, and the RxPass subscription ($5 a month) provides fast delivery on a list of commonly prescribed medications.

What consumers should know

  • Check your ZIP code: Same-day delivery wont be everywhere at launch, so see if your area is on the list as Amazon expands.

  • Compare costs: Even with speedy delivery, its worth comparing prices your insurance, local pharmacy deals, and Amazons discounts can vary.

  • Ask about kiosks: If you visit a One Medical clinic, you might be able to pick up your prescription before you even leave your appointment.

  • Consider convenience vs. control: Digital delivery is great for speed and accessibility, but some people still prefer the in-person care of a local pharmacist.


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Consumer News: The economy created 130,000 jobs in January, more than expected
Wed, 11 Feb 2026 20:07:07 +0000

The same three sectors continue to produce the most jobs

By Mark Huffman of ConsumerAffairs
February 11, 2026
  • U.S. economy added 130,000 jobs in January, as unemployment held at 4.3%.

  • Health care, social assistance, and construction led hiring, while federal government and financial jobs declined.

  • Annual benchmark revisions sharply lowered 2025 job growth totals.


If you are looking for a job, your prospects may be getting a little brighter. U.S. employers added 130,000 jobs in January, significantly more than expected.

The unemployment rate was unchanged at 4.3%, signaling a steady but restrained start to 2026. The latest figures from the Bureau of Labor Statistics (BLS) show modest job growth following a sluggish 2025, when payrolls expanded by an average of just 15,000 jobs per month.

Gains last month were concentrated in health care, social assistance, and construction, while federal government payrolls continued to shrink and financial sector employment declined.

Unemployment steady, but higher than a year ago

The jobless rate held at 4.3% in January, with 7.4 million Americans unemployed. That is little changefrom December, but up from 4.0% and 6.9 million unemployed a year earlier.

Teenagers saw some improvement, with their unemployment rate falling to 13.6%. Rates for adult men (3.8%), adult women (4.0%), and major racial and ethnic groups showed little monthly movement. Black workers continued to face a higher unemployment rate at 7.2%, compared with 3.7% for White workers, 4.1% for Asian workers, and 4.7% for Hispanic workers.

Long-term unemployment defined as those jobless for 27 weeks or more was essentially unchanged at 1.8 million in January. However, thathas risen by 386,000 over the past year. One in four unemployed workers has been out of work for at least six months.

The labor force participation rate remained at 62.5%, and the employment-population ratio held at 59.8%, both largely unchanged over the past year.

There was some relief in involuntary part-time employment. The number of people working part time for economic reasons fell by 453,000 to 4.9 million in January, though that figure remains higher than a year ago. Meanwhile, 5.8 million people outside the labor force said they wanted a job, down by 399,000 from December.

Health care drives job gains

Health care once again led job growth, adding 82,000 positions in January. Ambulatory health care services accounted for 50,000 of those jobs, while hospitals added 18,000 and nursing and residential care facilities contributed 13,000.

Social assistance employment rose by 42,000, primarily in individual and family services. Construction added 33,000 jobs, largely among nonresidential specialty trade contractors. Construction employment had been essentially flat throughout 2025.

Other major industries including manufacturing, retail trade, transportation and warehousing, professional and business services, and leisure and hospitality showed little change over the month.


Read More ...


Consumer News: Eddie Bauer LLC files for Chapter 11 bankruptcy protection
Wed, 11 Feb 2026 20:07:07 +0000

While some stores could close, online sales are not affected

By Mark Huffman of ConsumerAffairs
February 11, 2026
  • Eddie Bauer LLC has filed for Chapter 11 bankruptcy protection in New Jersey after reaching a restructuring agreement with its secured lenders.

  • The company will launch liquidation sales at its U.S. and Canadian stores while pursuing a potential sale of all or part of its retail operations.

  • E-commerce and wholesale operations, operated by Outdoor 5 LLC, are not affected and will continue as usual.


Eddie Bauer LLC, the operator of Eddie Bauer retail and outlet stores in the United States and Canada, has filed for Chapter 11 bankruptcy protection as part of a restructuring plan aimed at stabilizing the business and maximizing value for stakeholders. Some or all of the retail outlets could close.

The company announced it has entered into a Restructuring Support Agreement (RSA) with its secured lenders and has begun voluntary Chapter 11 proceedings in the U.S. Bankruptcy Court for the District of New Jersey. The agreement is intended to streamline the bankruptcy process and allow the retailer to move through it as quickly and efficiently as possible.

Some stores will close

As part of the restructuring, Eddie Bauers retail stores in the U.S. and Canada will remain open for now, but the company will begin liquidation sales as it winds down certain locations. At the same time, the company is actively seeking a buyer for all or part of its store operations in what it described as a dual-path strategy.

If a buyer is secured, the company may shift away from a full liquidation and instead complete a going-concern sale that preserves some or all of its store footprint. If no transaction materializes, the retailer said it will proceed with an orderly wind-down of store operations.

Marc Rosen, CEO of Catalyst Brands, said the company has faced mounting financial challenges that predate the formation of Catalyst Brands last year.

Inflation-driven cost increases

Even prior to the inception of Catalyst Brands last year, the retail company was in a challenged situation, with declining sales, supply chain challenges, and other issues, Rosen said in a statement. He added that those difficulties were compounded by inflation-driven cost increases, tariff uncertainty, and other economic pressures.

Rosen said that while Catalysts leadership team made progress in areas such as product development and marketing, those efforts were not enough to overcome longstanding operational and financial headwinds.

The company has filed several customary first-day motions with the bankruptcy court, including requests to use cash collateral to continue paying employee wages and benefits and to fund operations during the Chapter 11 process.

Online sales are not affected

Importantly for customers, Eddie Bauers online and wholesale businesses are not part of the bankruptcy filing. Those operations are run by a separate licensed operator, Outdoor 5 LLC (also known as Oved), and will continue without interruption. Authentic Brands Group retains ownership of the Eddie Bauer intellectual property and may license the brand to other operators in the future.

The filing does not affect Eddie Bauer stores outside the U.S. and Canada, which are operated by other licensees and will continue normal operations. Other brands within the Catalyst Brands portfolio are also not impacted by the bankruptcy.

Rosen acknowledged the impact of the decision on employees and business partners.


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Consumer News: New research explores why some people stay on weight-loss drugs that make them feel sick
Wed, 11 Feb 2026 20:07:06 +0000

The findings show perceived results often outweigh unpleasant side effects for semaglutide users

By Kristen Dalli of ConsumerAffairs
February 11, 2026

  • Many semaglutide (e.g., Ozempic) users keep taking the drug because they see real weight loss or appetite reduction.

  • A Rutgers study analyzed anonymous online reviews to understand what drives peoples decisions to continue or stop treatment.

  • Gastrointestinal side effects like nausea were common but didnt strongly deter users lack of results did.


Weight-loss medications like semaglutide often known by brand names such as Ozempic have become a huge part of the public conversation about obesity and body weight.

However, these drugs arent without downsides: many users report unpleasant side effects, especially gastrointestinal discomfort.

With all the buzz out there on social media, in the news, and across conversations about health researchers at Rutgers Health wanted to understand something deeper: when people actually use these medications in real life, what makes them stick with them or stop?

Ozempic has become a cultural phenomenon, but much of the public conversation has been driven by celebrity endorsements and social media trends rather than the voices of everyday users, researcher Abanoub Armanious, said in a news release.

Our study cuts through the noise to ask a simple question: What do people actually experience when they use this medication for weight loss, and what shapes their decision to keep going or stop?

The study

Instead of relying on data collected in a clinical trial setting, the Rutgers team used a method called infoveillance to tap into publicly available online health data.

They analyzed 60 anonymous, freely-posted medication reviews from a health information website. These reviews came from people who shared their own experiences using semaglutide for weight loss what they noticed about how it made them feel, what benefits they saw, and whether they planned to keep using it.

Rather than controlled clinical measurements, this approach centered on what real users say matters most to them in everyday life something often missing from traditional research.

By combing through these narratives and categorizing peoples reported outcomes and attitudes, the researchers could see patterns in satisfaction, persistence with the treatment, and reasons for discontinuing it.

What the results show

Heres what stood out: the biggest factor linked with both satisfaction and the intention to keep taking the drug was how effective people perceived it to be.

Most users who said they lost weight, ate less, or had fewer food cravings also said they planned to stick with the treatment, even if they experienced side effects like nausea or vomiting. Roughly two-thirds (67%) mentioned these positive effects.

On the flip side, people who didnt see much weight loss or who dealt with other, non-gastrointestinal side effects were more likely to say they would stop using the medication.

Interestingly, the common stomach-related side effects didnt strongly influence users overall decisions to continue suggesting that, for many, seeing results mattered more than feeling sick.

Theres been a lot of focus on the side effects of GLP-1 medications nausea, digestive issues and whether they're worth it, researcher Morgan James said in the news release.

What we found is that for many users, the calculus is straightforward: If the drug helps them lose weight, theyre willing to tolerate significant discomfort. That tells us something important about the demand for effective weight loss options and how we need to think about supporting such patients.

The authors emphasize that understanding patient experiences especially outside clinical settings can help doctors and patients have clearer conversations about expectations and side effects. They also suggest future studies should explore how attitudes might change over time or differ between groups of people.


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Consumer News: Slimmer passengers, cheaper flights? Weight-loss drugs could trim airline fuel costs
Wed, 11 Feb 2026 20:07:06 +0000

A medical trend on the ground could change costs in the sky

By Kyle James of ConsumerAffairs
February 11, 2026
  • Lighter passengers, lighter planes: A 10% drop in average passenger weight could cut total aircraft weight about 2%, trimming fuel use roughly 1.5% per flight.

  • Savings scale quickly: For major carriers like American Airlines, Delta Air Lines, Southwest Airlines, and United Airlines, that could mean about $580 million a year in fuel savings.

  • Fares likely wont fall: Ticket prices usually follow demand and competition, so lower fuel costs may lift profits more than cut prices.


A surprising side effect of Americas weight-loss boom could show up in the skies and not just on bathroom scales.

According to an analysis from Jefferies Research Services, widespread use of GLP-1 weight-loss medications like Ozempic and Wegovy could eventually lower airline fuel costs by making passengers lighter on average.

Airlines have long obsessed over shaving ounces, from lighter seats to thinner paper manuals. The one thing they cant control? Passenger weight.

Thats where these medications come in.

The math behind the savings

Jefferies modeled the impact on a Boeing 737 MAX 8, a common narrow-body jet used on domestic routes.

If the average passenger weight dropped by 10%, that total weight on the plane could fall by as much as 2%. That smaller load could translate to roughly 1.5% in fuel savings per flight.

Scaled across the industry, that adds up pretty fast. Jefferies estimates the four largest U.S. carriers American Airlines, Delta Air Lines, Southwest Airlines, and United Airlines could save about $580 million a year on fuel if average passenger weight fell meaningfully.

Together, those airlines are expected to spend nearly $39 billion on jet fuel this year.

Will travelers see cheaper tickets?

That sure would be nice, but it probably wont work that way.

Airlines historically do not lower airfare based on cost savings alone. They tend to base it more on travel demand (or lack thereof) along with what competing airlines are doing.

So in the end, lower fuel usage may improve airlines profits, but it wont necessarily make air travel cheaper.

Still, over time, lower operating costs can:

  • Help airlines keep fares from rising as fast.
  • Improve route profitability, potentially adding more flight options.
  • Boost airline earnings, which can stabilize the industry during downturns.

The bigger picture

This projection hinges on the assumption that GLP-1 drugs become widely used and lead to sustained weight loss across a large share of the population.

But it shows how deeply connected health trends and everyday consumer costs can be. A medical breakthrough aimed at waistlines could ripple into airfare pricing, airline profits, and even how carriers plan routes and fleets.


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