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The findings also highlight the long-term safety of the drug

By Kristen Dalli of ConsumerAffairs
May 15, 2024

Photo

While many consumers have turned to weight loss drugs recently, many questions about the medication still remain. Some of these questions include the long-term efficacy and safety of the drug.

Novo Nordisk, the manufacturer of the weight loss drug Wegovy (semaglutide), has been conducting an ongoing clinical trial the SELECT trial, and the four-year results have just been released.

According to the findings, participants were taking the drug for four years without any major adverse effects, and they continued to keep the weight off and continued to lose weight.

Our long-term analysis of semaglutide establishes that clinically relevant weight loss can be sustained for up to four years in a geographically and racially diverse population of adults with overweight and obesity but not diabetes, said research Professor Donna Ryan.

The four-year results

The researchers followed over 17,600 adults who were either overweight or obese, from over 800 countries, involved in the study. For 40 months, the participants were either treated with 2.4 mg of semaglutide each week or given a placebo.

Ultimately, the researchers found that participants who took the weight loss drug for four years maintained their weight loss.

Those taking Wegovy lost an average of 10.2% of their body weight and 7.7 cm off their waists over four years. Comparatively, those in the placebo group lost 1.5% of their body weight and 1.3 cm off their waists.

Lower body mass index

At the two-year mark, the researchers observed that 52% of participants taking Wegovy had moved into a lower BMI category. On the other hand, just 16% of those taking the placebo saw a significant reduction in their BMI.

Additionally, 12% of Wegovy-takers were able to move into a healthy BMI category, compared with just 1.2% of those in the placebo group.

The researchers found these statisticsheld up regardless of age, ethnicity, gender, geographic location, and baseline metabolic health.

This degree of weight loss in such a large and diverse population suggests that it may be possible to impact the public health burden of multiple obesity-related illnesses, Ryan said. While our trial focused on cardiovascular events, many other chronic diseases, including several types of cancer, osteoarthritis, and anxiety and depression would benefit from effective weight management.



Photo Credit: Consumer Affairs News Department Images


Posted: 2024-05-15 11:32:30

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Consumer News: Wegovy users keep the weight off after four years, study finds - Newscast

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Tue, 21 May 2024 09:48:00 GMT Nestlé is launching a line of food products tailored to people using weight-loss medication in an effort to capitalize on a market expected to reach $30 billion in the next six years.

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Tue, 21 May 2024 08:51:00 GMT Nestle will market a new, US$5 line of frozen pizzas and protein-enriched pastas in the U.S., which it says it designed specifically for people taking Wegovy or Ozempic.

Nestle to launch food products that cater to Wegovy and Ozempic users

Tue, 21 May 2024 08:12:00 GMT Nestle is launching a new line of high-fiber, protein-packed foods directed at the growing number of Americans on Wegovy or Ozempic, and others trying to lose weight.

Nestle is launching a food brand designed for Ozempic and Wegovy users

Tue, 21 May 2024 06:46:00 GMT Nestle is getting into the weight loss business. The world’s largest food and beverage company said it plans to launch a frozen food brand that will cater to consumers who use GLP-1 drugs such as ...


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