New study links paternal history to higher buildup of Alzheimers-related tau protein
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Adults with a father who had Alzheimers showed greater tau buildup, a key marker of the disease.
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Women in the study had more widespread tau in their brains than men.
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Findings could help guide personalized prevention strategies before memory loss begins.
Weve all heard how having a parent with Alzheimers could bump up our own risk of developing the disease but what if it matters which parent?
A recent study by the American Academy of Neurology reveals something surprising: it might actually be your dads history, not your moms, that correlates more strongly with a specific Alzheimers marker in the brain. While previous research often pointed to maternal inheritance, this study flips the narrative, focusing on how tau protein not just memory decline might have its own family story.
We were surprised to see that people with a father with Alzheimers were more vulnerable to the spread of tau in the brain, as we had hypothesized that we would see more brain changes in people with affected mothers, study author Sylvia Villeneuve, Ph.D. said in a news release.
The study
Researchers tracked 243 cognitively healthy adults, all around 68 years old, who had at least one parent (or two siblings) with Alzheimers. Importantly, none of the participants had any thinking or memory issues when the study began.
They underwent brain scans and memory testing, then were followed for almost seven years. Over that time, 71 people developed mild cognitive impairment often seen as an early step toward Alzheimers.
The team measured two key protein markers in the brain: beta-amyloid and tau. Tau buildup is especially linked to Alzheimers disease.
The results
The researchers discovered a paternal pattern throughout the study.
Participants whose fathers had Alzheimers showed a greater spread of the tau protein in their brains. This was a surprising finding especially since the team expected maternal influence to be stronger.
Additionally, gender mattered too. Women in the study had a heavier tau buildup than men and were more likely to show widespread tau protein spread.
Its important to note that these findings are associations, not proof of direct cause. Additionally, the study participants were mostly white, so the findings may not apply equally across all races and ethnicities.
However, the researchers explained that these insights might help health care professionals design personalized interventions that protect those at higher risk before symptoms even surface.
Better understanding these vulnerabilities could help us design personalized interventions to help protect against Alzheimers disease, Dr. Villeneuve said.
Posted: 2025-07-18 19:37:50